SLC15 family of peptide transporters in GtoPdb v.2021.3
نویسندگان
چکیده
The Solute Carrier 15 (SLC15) family of peptide transporters, alias H+-coupled oligopeptide cotransporter family, is a group membrane transporters known for their key role in the cellular uptake di- and tripeptides (di/tripeptides). Of its members, SLC15A1 (PEPT1) chiefly mediates intestinal absorption luminal di/tripeptides from overall dietary protein digestion, SLC15A2 (PEPT2) mainly allows renal tubular reuptake ultrafiltration brain-to-blood efflux choroid plexus, SLC15A3 (PHT2) SLC15A4 (PHT1) interact with both histidine, e.g. certain immune cells, SLC15A5 has unknown physiological function. In addition, SLC15 variably interacts very large number peptidomimetics peptide-like drugs. It conceivable, based on currently acknowledged structural functional differences, to divide into two subfamilies [3].
منابع مشابه
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ژورنال
عنوان ژورنال: IUPHAR/BPS guide to pharmacology CITE
سال: 2021
ISSN: ['2633-1020']
DOI: https://doi.org/10.2218/gtopdb/f187/2021.3